Also, katzung pharmacology pdf or the basic and clinical pharmacology offers comprehensive text to help you develop crystal clear concepts regarding the clinical use of drugs. Thiazide diuretics belong to a chemical class of drugs called sulfonamides. The subgroups of the sodiumexcreting diuretics are based on these sites and processes in the nephron. Clinical pharmacology of antihypertensive therapy for the. Diuretic drugs clarise elefante shirley garay daniel alexei garcia 2. Each type works in a distinct way and in different parts of the kidney. In this video i discuss the various types of diuretics, loop diuretics, thiazide diuretics, potassium sparing diuretics and osmotic diuretics. Which of the following puts the drugs in the correct order. Diuretics, commonly called water pills, are drugs that promote diuresis, that is increased production of urine.
Choose from 500 different sets of pharmacology quiz 1 diuretics flashcards on quizlet. Associate professor of pharmacology, seton hall college of medicine and dentistry, jersey city, n. Antihypertensive drugs have, then, never been more important. When we talk about the pharmacology of antihypertensive drugs, were talking about a very large and diverse family of medicines see below.
Including uses, types, side effect, and drug interaction. Diuretic drugs medications that augments diuresis commonly known as water pills homeopathic remedies or foods that help to prevent or treat fluid retention used to treat heart failure, liver cirrhosis, hypertension and certain kidney diseases. Diuretic drugs are typically classified first according to their predominant site of action along the nephron and second by the mechanism by which they inhibit transport figure 1a. Wolters kluwer health is a leading provider of information for professionals and students in medicine, nursing, allied health, pharmacy and the pharmaceutical industry. This blog post is an effort dedicated to making pharmacology easier just a bit and fun quite unlikely by the use of mnemonics. Along with diet and exercise, they remain one of the most effective methods to reduce high blood pressure. Titrate single daily dose up to ceiling dose as needed thiazide diuretic. Yet other classes of drugs, including antihypertensives, antibiotics, and antivirals, may also interact with these transporters and cause resistance 35. They exert most of their therapeutic effects through inhibiting the reabsorption of sodium at different sites along the nephron of the kidney. The effects of the diuretic agents are predictable from knowledge of the function of the segment of the nephron in which they act. Describes pharmacology of diuretic drugs authorstream presentation.
They are filtered at the glomerulus some are also sec by the weak acid sec. Diuretic, any drug that increases the flow of urine. Among these drugs, loop diuretics such as furosemide are perhaps the most frequently prescribed, and their clinical pharmaco. Diuretics promote the removal from the body of excess water, salts, poisons, and accumulated metabolic products, such as urea. Learn pharmacology quiz 1 diuretics with free interactive flashcards. The loop diuretics furosemide, bumetanide, and torsemide act from the lumen to inhibit the nak2cl cotransporter nkcc2, encoded by slc12a1 along the thick. Clinical pharmacology of diuretic drugs sciencedirect. Central nervous system effects of which one of the following drugs are thought to result primarily from its conversion to morphine in the brain. Download antidiuretics pharmacology notes pdf, study material, ebooks for mbbs and other pharmacology notes free from. Thus, in settings of decreased renal function, doses must be increased to deliver more diuretic into the urine.
Clinical pharmacology in diuretic use american society. During intravenous therapy with ntg, if blood pressure bp drops and ischemia is not relieved, the addition of phenylephrine will allow coronary perfusion pressure cpp to be maintained while allowing higher doses of ntg to be used for ischemia relief. Most diuretics produce diuresis by inhibiting the reabsorption of sodium at different segments of the renal tubular system. Diuretics is part of the lecturio course cardiovascular pharmacology watch the complete course on. Diuretics pdf diuretics pharmacology pdf diuretics classification pdf. Diuretics iv lasix to start, oral loop diuretic later, and thiazide prn should he need it. Diuretic drugs increase urine output by the kidney i. Diuretics are among the most commonly prescribed drugs, and play an important role in the treatment of heart failure and hypertension. For this reason, it is frequently taken alongside another diuretic such as a loop or thiazide diuretic to counteract potassium loss and promote overall diuresis.
Problems in the human pharmacology of diuretic drugs. Diuretic drugs are widely used for the treatment of patients with edema. More than 99% of the glomerular filtrate is reabsorbed in the tubules, about 1. Diuretic drug groups the diuretics acting in these segments each have different moa. All but spironolactone must reach the lumen or urinary side of the nephron to exert their effects. Thiazidelike diuretics have different chemical structure but work in the same. Diuretics free download as powerpoint presentation. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
May 15, 2018 diuretics also called water pills are drugs that increase urine production in the kidneys, promoting the removal of salt and fluid from the body. Faqs information on diuretic drugs and the diseases and conditions they are prescribed for. Nonsteroidal antiinflammatory drugs nsaids inhibit diuretic secretion and alter diuretic responsiveness, and because of their frequent use, are an important cause of heart failure exacerbations. Pharmacy diuretics free download as powerpoint presentation. The diuretics in our therapeutic armamentarium have predictable effects based on their nephron sites of action. They serve to rid the body of excess fluid that accumulates in the tissues owing to various disease states. Jun 28, 2014 diuretic drug groups the diuretics acting in these segments each have different moa. Reducing the amount of fluid in the blood vessels results in reduction in blood pressure.
Scribd is the worlds largest social reading and publishing site. Problems in the human pharmacology of diuretic drugs dr. The clinical pharmacology of potassiumsparing diuretics is important. Mnemonics are a great way to help ease the pressure on your nerves and they can be very helpful for remembering drug names and their side effects. Jun 08, 2019 diuretic agents are used in the management of glaucoma by enhancing the osmotic pull to effectively remove some fluid in the eye, decreasing the iop. Which of the following is a potassium losing diuretic. Diuretic agents increase the urine formation, by influencing any of the processes involved in urine formation.
Pharmacology of diuretics authorstream presentation. Easy to remember pharmacology mnemonics with pictures. Spironolactone is a weak diuretic that takes several days to take effect. The clinical pharmacology of these drugs is described and an overall regimen for the treatment of cardiac edema is outlined. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. As a major modifiable risk factor for cardiovascular disease in this highrisk population, treatment of hypertension in ckd is important. Several other drugs alter water excretion predominantly.
Likewise, you will be able to access 400 colorful illustrations depicting the mechanism of action of drugs and their adverse effects. Pharmacology and clinical use of diuretics katie herndon, pharm. A comparative pharmacological study of diuretic drugs. Katzung pharmacology 14th edition pdf 12 and th editions. Najeeb lectures are the worlds most popular medical lectures. Pharmacology 501801 practice final exam february 22, 2005. Knowledge from the various pharmacologic classes enables the nurse to understand how drugs work in the body, to achieve the therapeutic. Diuretics work on the kidneys to eliminate water and. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects.
Crcl 50, use 25 to 50 mgd hctz crcl 20 to 50, use 50 to 100 mgd hctz crcl diuretic. Pharmacology pharmacology is the study of the actions of drugs, incorporating knowledge from other interrelated sciences, such as pharmacokinetics and pharmacodynamics. Pharmacology of antihypertensive drugs your complete guide. Chronic renal failure nephrotic syndrome cirrhosis mild chf moderate or severe chf loop diuretic. Jan 06, 2018 these substances increase the excretion of water, sodium, and chloride through urine.